Gamma Brief Lab

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Alpha, beta, Auger: where the dose goes

Particle range at cellular scale and dose to organs at risk for ¹⁷⁷Lu, ²²⁵Ac and ¹⁶¹Tb bound to PSMA-617

organ doses: Published datatolerance thresholds: Order of magnitude3D scene: Illustrative Under review

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Sources

  1. Kratochwil C, Bruchertseifer F, Rathke H, et al. Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: dosimetry estimate and empiric dose finding. J Nucl Med. 2017;58(10):1624-1631. · doi:10.2967/jnumed.117.191395
  2. Herrmann K, Rahbar K, Eiber M, et al. Renal and multiorgan safety of 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer in the VISION dosimetry substudy. J Nucl Med. 2024;65(1):71-78. · doi:10.2967/jnumed.123.265448
  3. Schaefer-Schuler A, Burgard C, Blickle A, et al. [161Tb]Tb-PSMA-617 radioligand therapy in patients with mCRPC: preliminary dosimetry results and intra-individual head-to-head comparison to [177Lu]Lu-PSMA-617. Theranostics. 2024;14(5):1829-1840. · doi:10.7150/thno.92273
  4. Sandström M, Garske-Román U, Granberg D, et al. Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment. J Nucl Med. 2013;54(1):33-41. · doi:10.2967/jnumed.112.107524
  5. Wahl RL, Dewaraja YK. Dosimetry-driven personalization of radiopharmaceutical therapies. J Nucl Med. 2026;67(Suppl 2):60S-78S. · doi:10.2967/jnumed.125.269488
  6. Deasy JO, Moiseenko V, Marks L, et al. Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S58-S63. · doi:10.1016/j.ijrobp.2009.06.090
  7. Hindié E, Zanotti-Fregonara P, Quinto MA, Morgat C, Champion C. Dose deposits from 90Y, 177Lu, 111In, and 161Tb in micrometastases of various sizes: implications for radiopharmaceutical therapy. J Nucl Med. 2016;57(5):759-764. · doi:10.2967/jnumed.115.170423

v3.0.0 · last verified 2026-10-01